Backtracking of newly synthesized amyloid precursor protein from the Golgi to the ER facilitates APP modification and Aβ production.
C9ORF72 repeats create RNA foci and dipeptide aggregates in mice, but antisense oligonucleotides suppress them.
Two new papers rekindle acrimonious debate about exactly what “loss-of-function” means when it comes to presenilin mutations in Alzheimer’s pathogenesis.
Citing “fantastic opportunity,” FDA and EMA call for rigorous science. Agency scientists tell FTD Treatment Study Group: Explore individualized outcomes, and connect biomarkers to meaningful improvement.
Hoping for better luck in clinical trials than their Alzheimer’s colleagues had in the past decade, FTD researchers are now chasing biomarkers. It’s slim pickings so far, but neurofilament, tau PET, and MRI are showing promise.
By examining polymorphisms linked to autoimmune diseases, researchers pinned two loci to Alzheimer’s risk. Both may worsen neurofibrillary tangle pathology.
Exome sequencing in families with amyotrophic lateral sclerosis and frontotemporal dementia yields variants of a gene that helps recycle cellular waste.
At a workshop of the Frontotemporal Dementia Treatment Study Group, advocates and regulatory scientists urged leaders from industry and academia to forge a collaborative approach while the field is still young.
A growing number of studies have hinted that neurogranin may be a promising biomarker for Alzheimer’s disease. How promising? New meta-analyses by Henrik Zetterberg and Bob Olsson suggest that the synaptic protein is elevated nearly twofold in the cerebrospinal fluid of people with Alzheimer’s relative to controls. Baseline levels are also higher in people with MCI who go on to develop Alzheimer’s dementia, compared to those who do not. Plasma levels do not appear to correlate with disease. View the aggregated data and analyses in AlzBiomarker and stay tuned for further additions to the database.
- Maria Teresa Ferretti, M. Florencia Iulita and Sonia Do Carmo on Paper Alert: Microglia Mediate Synaptic Loss in Early Alzheimer’s Disease
- Petra Kashi on New Genetic Method Connects Immune Genes to Alzheimer’s
- Wataru Araki on New Gene Strengthens Link Between ALS and FTD
- John Hardy on New Genetic Method Connects Immune Genes to Alzheimer’s
- Kaj Blennow on CSF Tau Rivals Aβ for Predicting Cognitive Decline
- Walter A. Rocca on Dementia Incidence in Britain Dropped, Mostly in Men
- Chengxuan Qiu on Dementia Incidence in Britain Dropped, Mostly in Men
- Eric Larson on Dementia Incidence in Britain Dropped, Mostly in Men
- Suzanne de la Monte on Diabetic Monkeys Show Signs of Early Alzheimer’s
- Stephen Salloway on CSF Tau Rivals Aβ for Predicting Cognitive Decline
- Timothy Miller on Mexiletine Banishes Muscle Cramps in Phase 2 Trial of ALS