Phase 1 trial tests the rejuvenating effects of young blood, while albumin replacement may offer its own benefits.
According to a press release by trial sponsor Ionis, therapy was well tolerated, but trial results have yet to be released.
In a Phase 2 trial in nursing home residents with Alzheimer’s, this new drug mitigated symptoms safely, without detriment to cognition.
Gradually raising the dose of this therapeutic antibody appears to ease the risk of brain inflammation.
Presented at CTAD, BACE inhibitor’s efficacy and safety results in mild to moderate AD were encouraging to some clinicians, vaguely disquieting to others.
Recruitment, recruitment, recruitment: Registries get creative in how they promote research engagement and fill prevention trials.
Who doesn’t dread hours of testing at a clinic? Innovation needed! Learn about frequent “burst” testing via mobile app, and a digital pen that captures more information than the old paper-and-pencil test.
In people who carry a repeat expansion in the C9ORF72 gene, gray and white matter are smaller and subtle impairments in cognition appear decades before symptom onset.
In a Phase 2 trial, the serotonin receptor antagonist mitigated symptoms of psychosis in people with Alzheimer’s dementia, with a good safety profile and no deleterious effect on cognition. Better drugs are needed to replace traditional antipsychotics, whose use in dementia patients brings little benefit and much risk.
With more, larger, and earlier stage clinical trials coming online for Alzheimer’s disease, researchers are hitting a recruitment bottleneck. How to find people in their 50s and 60s who do not yet know they may be on the path to Alzheimer’s? Online registries, local ApoE genotyping parties, booths at community events, deeply phenotyped cohorts, electronic health records—a variety of approaches are being explored to engage potential participants and massively increase the number of people joining prevention research. Is it working? Read our CTAD update.
To improve cognitive testing, go digital, go home, and test yourself often. That’s according to researchers at the recent CTAD conference in Boston. A smartphone app that allows frequent, brief evaluations in the course of daily life dramatically increased the reproducibly of cognitive testing over in-clinic test sessions. A digital pen turned the old-fashioned clock-drawing test into a sensitive detector of subtle cognitive impairment. Both approaches should help efforts to find and follow people with the earliest signs of AD for prevention and treatment trials. In turn, trials should suss out participants’ rates of decline with frequent measures.
Tau PET is emerging as the favored biomarker to gauge disease progression for AD trials, according to researchers gathered at the 10th Clinical Trials on Alzheimer’s Disease conference in Boston. For AD and other tauopathies, the Piramal probe looks promising and a Merck compound is preparing to burst on the scene. New data offer a first look at PET measurements of synaptic loss.
Decades after its discovery, scientists are still trying to figure out how ApoE4 increases the risk for late-onset AD. Now, two new mouse studies suggest the gene works most of its mischief before plaques even form. Using opposite methods, ApoE suppression versus overexpression, both studies found that the E4 allele triggered initial Aβ aggregation and deposition, but had little effect on subsequent amyloid accumulation. The findings imply that therapies directed against ApoE would work best in a prevention paradigm.
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